Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

Published by BioScientifica

Page 2 of about 38 results

ea0024p2 | (1) | BSPED2010

Optimization of treatment in children with 21-hydroxylase deficiency using cortisol profiling

Logan K , Peters C , Hindmarsh P , Dattani M

Introduction: A number of different parameters are used to assess adequacy of treatment in children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Hydrocortisone day curves are established practice in our unit. To determine the value of this procedure, outcomes were monitored using the European Society for Paediatric Endocrinology 2002 guidelines for the management of 21-hydroxylase deficiency.Methods: Two hourly cortisol profiles ...
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ea0015p351 | Thyroid | SFEBES2008

Discrepancy between free thyroid hormones and thyrotropin values in patient with Hashimotos thyroiditis

Abouglila Kamal , Ullah Arif , Cooper Helen , Thirugnanasothy Logan , Day Julie

Background: Measurements of thyrotropin (TSH), free thyroxine (FT4) and triiodothyronine (FT3) are widely used diagnostic methods for thyroid function evaluation. However, some serum samples will demonstrate a nonspecific binding with assay reagents that can interfere with the measurement of these hormones. Few case reports of TSH interfering antibodies have described the presence of such interferences resulting in reported abnormal concentrations of thyroid hormones. Unusual ...
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ea0015p354 | Thyroid | SFEBES2008

Hypo-osmolar hyponatremia and orthostatic hypotension as the chief symptom in primary hypothyroidism

Ullah Arif , Abouglila Kamal , Thirugnanasothy Logan , Cooper Helen

Background: Postural hypotension has been commonly described in elderly. Common causes include medication, fluid loss, adrenal insufficiency and autonomic dysfunction. Hyponatremia is not a disease in itself, but a manifestation of a variety of disorders and side-effects of diuretics; alternatively, it may be the only manifestation of certain disorders. We present a case of primary hypothyroidism presenting as collapse with postural hypotension and severe hyponatremia.<p c...
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ea0015p355 | Thyroid | SFEBES2008

Sunitinib induced hypothyroidism in gastrointestinal stromal tumours

Cooper Helen , Abouglila Kamal , Ullah Arif , Thirugnanasothy Logan

Background: Sunitinib is a tyrosine kinase inhibitor used in the treatment of metastatic GIST and renal cell carcinoma. Tyrosine kinase receptors are involved in tumour growth, angiogenesis and metastatic invasion. It can cause hypothyroidism but few cases have actually been reported. Mechanisms suggested for the incidence of hypothyroidism include antithyroperoxidase activity,1 and blocking uptake of iodine in the thyroid gland,2 or it may induce destruc...
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ea0013p127 | Growth and development | SFEBES2007

Neural stem cell differentiation in the injured adult mouse brain

Leadbeater Wendy , Summerfield Michael , Berry Martin , Logan Ann

Constitutive neurogenesis in the adult mammalian brain (sub-ventricular zone, SVZ and dentate gyrus) implies the capacity for self-repair following brain injury. However, brain injury is usually permanently debilitating as neuronal self-repair responses are not sustained and resident neural stem cells (NSC) do not repopulate damaged tissue. Identification of NSC differentiating factors transiently activated post-injury will be key to enhancing NSC mobilisation and differentiat...
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ea0011p333 | Diabetes, metabolism and cardiovascular | ECE2006

Adult pancreatic islet progenitor cells exhibit plasticity in vitro

Leadbeater WE , Summerfield MR , Hill DJ , Berry M , Logan A

Adult progenitor cells exist in most adult tissues, their differentiation being primed by insult, repopulating damaged or dysfunctional tissue. Utilisation of resident progenitor cells has the potential to cure many diseases, including neurodegenerative disorders or diabetes which presently can only be managed. This potential is limited in the brain by constraints on endogenous progenitor cell mobilisation and by difficulties in progenitor cell harvesting for ex vivo ex...
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ea0010p26 | Cytokines, growth factors, growth and development | SFE2005

Ahmed Z , Mazibrada G , Dent R , Berry M , Logan A

Upon binding of myelin-derived axon growth inhibitory ligands to the Nogo receptor (NgR), a complex is formed with LINGO-1 and the low affinity neurotrophin receptor p75NTR, which initiates axon growth cone collapse via a Rho-A-mediated pathway. We reasoned that, after tumor necrosis factor-α converting enzyme (TACE) cleavage of p75NTR, which triggers the initiation of regulated intramembrane proteolysis (RIP), signalling of growth cone collap...
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ea0008go2 | (1) | SFE2004

siRNA-Mediated Knock Down of NgR, p75NTR and Rho-A Disinhibits Neurotrophin-Induced Dorsal Root Ganglia Neurite Outgrowth on CNS Myelin

Ahmed Z , Dent RG , Suggate EL , Berry M , Logan A

Central nervous system neurones are generally incapable of regenerating their axons after injury due to the limited availability of neurotrophins, the development of a glial scar, and the presence of multiple axon growth inhibitors. We therefore designed short interfering RNA (siRNA) sequences to knock down components of the inhibitory signalling cascade and tested their ability to disinhibit the growth of FGF2-stimulated dorsal root ganglia neurone (DRGN) neurites in the pres...
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ea0077p6 | Adrenal and Cardiovascular | SFEBES2021

The effect of plasma potassium on hospital length of stay in unselected acute admissions

Ellis Hugh Logan , Sharpe Claire , Kelly Philip , Al-Agil Mohammad , Teo James , Whyte Martin

Introduction: Hypo-&hyperkalaemia are common laboratory abnormalities, complicating up to 10% of all hospital admissions and contributing to mortality. Ideally, patients with mild deviations can be treated as outpatients, and only those patients with objectively severe or life-threatening levels are hospitalized. Once admitted, there are few data as to whether the degree of electrolyte disturbance consumes greater resource(s). We analysed the admission and discharge data, ...
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ea0077p90 | Neuroendocrinology and Pituitary | SFEBES2021

Hypo and hypernatraemia on admission are associated with increased length of stay in unselected acute hospital admissions

Ellis Hugh Logan , Sharpe Claire , Kelly Phil , Al-Agil Mohammad , Teo James , Aylwin Simon , Whyte Martin

Introduction: Hyponatraemia is a common biochemical abnormality, complicating up to 15% of all hospital admissions and associated with increased mortality. Hypernatraemia, occuring less frequently, is strongly associated with mortality and is almost always due to a free water deficit. There is limited data about hospital healthcare burden of these two relatively common electrolyte imbalances. We analysed the length of stay, for acute admissions, with reference to the admission...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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